FLAVONOID CONTENTS ANTIOXIDANT AND NEUROPROTECTIVE ACTIVITIES OF CRATAEGUS MONOGYNA JACQ. LEAVES AND FLOWERS

Antioxidant activities of Crataegus species' leaves and fruits so far have been reported in literature, however, several factors ranging from plant part(s), harvest season, the species and the geographical origin of the plant extensively impede and influence these antioxidant activities. In this research, ethanolic extracts of leaves and flowers of Crataegus monogyna Jacq. (CRT) collected from 6 different locations (Karaman, Bolu, Sinop, Egirdir, Elbistan, Seydisehir: CRT-1 to CRT-6) between May and June 2018 were evaluated for their flavonoid contents, antioxidant (RSA and PRAP assays) and neuroprotective capacities (SHSY5Y). Content of flavonoids epicatechin and hyperoside detected using HPLC is reported. Both CRT-3 and CRT-4 are remarkable in cycles of flavonoid content, antioxidant, and neuroprotective activities. Results show that leaves and flowers of C. monogyna provide considerable antioxidant protection and neuroprotective activity and can be a suitable raw material for medicine, food, and cosmetic industries.