Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples

被引:10
|
作者
Cai, Peishan [1 ,2 ]
Xiong, Xiang [1 ,2 ]
Li, Dan [1 ]
Zhou, Yu [1 ]
Xiong, Chaomei [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Dept Pharmaceut Anal, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pharm, Wuhan 430022, Peoples R China
基金
中国国家自然科学基金;
关键词
antidepressants; magnetic solid-phase extraction; MSPE; octadecyl-functionalized magnetic silica nanoparticles; plasma; UHPLC-MS/MS; urine; TANDEM MASS-SPECTROMETRY; SEROTONIN REUPTAKE INHIBITORS; LIQUID-LIQUID MICROEXTRACTION; WHOLE-BLOOD; MAIN METABOLITES; SIMULTANEOUS QUANTIFICATION; NONTRICYCLIC ANTIDEPRESSANTS; QUANTITATIVE-DETERMINATION; PORE-WALLS; CHROMATOGRAPHY;
D O I
10.4155/bio-2019-0171
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Aim: Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug-drug interactions or overlapping toxicity. Materials & methods: A magnetic solid-phase extraction by using C-18-functionalized magnetic silica nanoparticles (C-18-Fe3O4@SiO2 NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC-MS/MS assay. Results: The synthesized C-18-Fe3O4@SiO2 NPs showed high magnetization and efficient extraction for the analytes. After cleanup by magnetic solid-phase extraction, no matrix effects were found in plasma and urine matrices. The analytes showed LODs among 0.15-0.75 ng ml(-1), appropriate linearity (R >= 0.9990) from 2.5 to 1000 ng ml(-1), acceptable accuracies 89.1-110.9% with precisions <= 11.0%. The protocol was successfully applied for the analysis of patients' plasma and urine samples. Conclusion: It shows high potential in routine therapeutic drug monitoring of clinical biological samples.
引用
收藏
页码:35 / 52
页数:18
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