Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH•H2O

被引：9

作者：

Sajadikhah, Seyed Sajad ^{[1
]}

Maghsoodlou, Malek Taher ^{[2
]}

Hazeri, Nourallah ^{[2
]}

机构：

[1] Islamic Azad Univ, Najafabad Branch, Dept Chem, Fac Sci, Najafabad, Esfahan, Iran

[2] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, Zahedan, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 04期

关键词：

Dihydropyrrol-2-one; Heterocycle; p-TsOH center dot H2O; Four-component reaction; MULTICOMPONENT SYNTHESIS; DOMINO REACTION; INHIBITORS; ACETYLENEDICARBOXYLATES; 1,5-DIHYDROPYRROL-2-ONES; DIHYDROPYRROLES; DERIVATIVES; ARYLAMINES; ACIDS;

D O I：

10.1007/s11164-013-1364-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and straightforward procedure has been developed for synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via one-pot four-component domino reaction of amines, dialkyl acetylenedicarboxylates, and formaldehyde, in the presence of p-TsOH center dot H2O (15 mol%), in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, high to excellent yields, shorter reaction times, atom economy, easy operation, and no column chromatographic separation.

引用

页码：2503 / 2511

页数：9

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[1] Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH·H2O
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Malek Taher Maghsoodlou
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Research on Chemical Intermediates, 2015, 41 : 2503 - 2511
[2] Erratum to: Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH·H2O
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[3] Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH•H2O (vol 41, pg 2503, 2015)
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