High-Molecular-Weight HPMA-Based Polymer Drug Carriers for Delivery to Tumor

被引：24
|
作者：
Kostka, L. [1 ]
Etrych, T. [1 ]
机构：
[1] Czech Acad Sci, Inst Macromol Chem, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2016年 / 65卷
关键词：
Nanotherapeutics; pH responsive; HPMA copolymers; CANCER-CHEMOTHERAPY; ANTITUMOR-ACTIVITY; COPOLYMERS; ACCUMULATION; DOXORUBICIN; PHARMACOKINETICS; BIODISTRIBUTION; THERAPEUTICS; ARCHITECTURE; PROTEINS;
D O I：
10.33549/physiolres.933420
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl) methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.
引用
收藏
页码：S179 / S190
页数：12
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