Association of the diversity and composition of the gut microbiome with responses and survival (PFS) in metastatic melanoma (MM) patients (pts) on anti-PD-1 therapy.

被引：19
|
作者：
Wargo, Jennifer Ann [1 ]
Gopalakrishnan, Vancheswaran [1 ]
Spencer, Christine [1 ]
Karpinets, Tatiana [1 ]
Reuben, Alexandre [1 ]
Andrews, Miles Cameron [1 ]
Tetzlaff, Michael T. [1 ]
Lazar, Alexander [1 ]
Hwu, Patrick [1 ]
Hwu, Wen-Jen [1 ]
Glitza, Isabella Claudia [1 ]
Tawbi, Hussein Abdul-Hassan [1 ]
Patel, Sapna Pradyuman [1 ]
Lee, Jeffrey Edwin [1 ]
Davies, Michael A. [1 ]
Gershenwald, Jeffrey E. [1 ]
Futreal, Andrew [1 ]
Sharma, Padmanee [1 ]
Allison, James Patrick [1 ]
Jenq, Robert R. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷
关键词：
D O I：
10.1200/JCO.2017.35.15_suppl.3008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3008
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Response to anti-PD-1 based therapy in metastatic melanoma patients is associated with the diversity and composition of the gut microbiome
    Gopalakrishnan, Vancheswaran
    Spencer, Christine
    Reuben, Alexandre
    Prieto, Peter
    Vicente, Diego
    Karpinets, Tatiana V.
    Hudgens, Courtney W.
    Hutchinson, Diane S.
    Tetzlaff, Michael
    Lazar, Alexander
    Davies, Michael A.
    Gershenwald, Jeffrey E.
    Jenq, Robert
    Hwu, Patrick
    Sharma, Padmanee
    Allison, James
    Futreal, Andrew
    Ajami, Nadim
    Petrosino, Joseph
    Daniel-MacDougall, Carrie
    Wargo, Jennifer A.
    CANCER RESEARCH, 2017, 77
  • [2] Association of diversity and composition of the gut microbiome with differential responses to PD-1 based therapy in patients with metastatic melanoma.
    Gopalakrishnan, Vancheswaran
    Spencer, Christine
    Reuben, Alexandre
    Karpinets, Tatiana
    Hutchinson, Diane
    Hoffman, Kristi
    Prieto, Peter A.
    Tetzlaff, Michael T.
    Lazar, Alexander
    Davies, Michael A.
    Gershenwald, Jeffrey E.
    Jenq, Robert R.
    Hwu, Patrick
    Sharma, Padmanee
    Allison, James Patrick
    Futreal, Andrew
    Ajami, Nadim
    Petrosino, Joseph
    Daniel-MacDougall, Carrie
    Wargo, Jennifer A.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (07)
  • [3] Clinical correlates of response to anti-PD-1 (aPD1)-based therapy in patients (pts) with metastatic melanoma (MM).
    Davis, Elizabeth J.
    Zhao, Shilin
    Ye, Fei
    Rappazzo, Katherine
    Sosman, Jeffrey Alan
    Johnson, Douglas Buckner
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [4] Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
    Gopalakrishnan, V.
    Spencer, C. N.
    Nezi, L.
    Reuben, A.
    Andrews, M. C.
    Karpinets, T. V.
    Prieto, P. A.
    Vicente, D.
    Hoffman, K.
    Wei, S. C.
    Cogdill, A. P.
    Zhao, L.
    Hudgens, C. W.
    Hutchinson, D. S.
    Manzo, T.
    de Macedo, M. Petaccia
    Cotechini, T.
    Kumar, T.
    Chen, W. S.
    Reddy, S. M.
    Sloane, R. Szczepaniak
    Galloway-Pena, J.
    Jiang, H.
    Chen, P. L.
    Shpall, E. J.
    Rezvani, K.
    Alousi, A. M.
    Chemaly, R. F.
    Shelburne, S.
    Vence, L. M.
    Okhuysen, P. C.
    Jensen, V. B.
    Swennes, A. G.
    McAllister, F.
    Sanchez, E. Marcelo Riquelme
    Zhang, Y.
    Le Chatelier, E.
    Zitvogel, L.
    Pons, N.
    Austin-Breneman, J. L.
    Haydu, L. E.
    Burton, E. M.
    Gardner, J. M.
    Sirmans, E.
    Hu, J.
    Lazar, A. J.
    Tsujikawa, T.
    Diab, A.
    Tawbi, H.
    Glitza, I. C.
    SCIENCE, 2018, 359 (6371) : 97 - 103
  • [5] The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
    Matson, Vyara
    Fessler, Jessica
    Bao, Riyue
    Chongsuwat, Tara
    Zha, Yuanyuan
    Alegre, Maria-Luisa
    Luke, Jason J.
    Gajewski, Thomas F.
    SCIENCE, 2018, 359 (6371) : 104 - +
  • [6] A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition
    Pietrzak, Bernadeta
    Tomela, Katarzyna
    Olejnik-Schmidt, Agnieszka
    Galus, Lukasz
    Mackiewicz, Jacek
    Kaczmarek, Mariusz
    Mackiewicz, Andrzej
    Schmidt, Marcin
    CANCERS, 2022, 14 (21)
  • [7] "Interchangeability" of anti-PD1 antibodies in patients (pts) with metastatic melanoma (mM)
    Kravchuk, Darya
    Fedyanin, Mikhail
    Rays, Anastasia
    Moiseenko, Fedor Vladimirovich
    Ivanilov, Kirill
    Popov, Vladimir
    Glazkova, Elena
    Chubenko, Viacheslav
    Levchenko, Evgeny
    Volkov, Nikita
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [8] Patterns of acquired resistance to anti-PD-1 antibodies in patients with metastatic melanoma (MM).
    Lee, Jenny H. J.
    Cooper, Adam James
    Lyle, Megan Kate
    Liniker, Elizabeth
    Menzies, Alexander M.
    Kefford, Richard
    Long, Georgina V.
    Carlino, Matteo S.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [9] Safety and Activity of Combined Radiation Therapy (RT) and Anti-PD-1 Antibodies (PD-1) in Patients (pts) With Metastatic Melanoma
    Liniker, E.
    Kong, B.
    Menzies, A. M.
    Cooper, A. J.
    Kefford, R. F.
    Fogarty, G. B.
    Guminski, A.
    Carlino, M. S.
    Wang, T. W.
    Long, G. V.
    Hong, A.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2015, 93 (03): : E635 - E635
  • [10] Clinical models to predict response and survival in metastatic melanoma (MM) patients (pts) treated with anti-PD-1 alone (PD1) or combined with ipilimumab (IPI+PD1).
    Da Silva, Ines Esteves Domingues Pires
    Ahmed, Tasnia
    Lo, Serigne
    Rai, Rajat
    Smith, Jessica Louise
    Park, John J.
    Nabhan, Caroline
    Scolyer, Richard A.
    Carlino, Matteo S.
    McQuade, Jennifer Leigh
    Johnson, Douglas Buckner
    Long, Georgina V.
    Menzies, Alexander M.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
12345