Ubiquitin-Conjugating Enzymes in Cancer

被引：31

作者：

Bui, Quyen Thu ^{[1
,2
]}

Hong, Jeong Hee ^{[3
]}

Kwak, Minseok ^{[4
]}

Lee, Ji Yeon ^{[5
]}

Lee, Peter Chang-Whan ^{[1
,2
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Sci, Seoul 05505, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Lung Canc Res Ctr, Seoul 05505, South Korea

[3] Gachon Univ, Coll Med, Dept Physiol, Incheon 21999, South Korea

[4] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea

[5] Catholic Univ, Seoul St Marys Hosp, Dept Med, Div Rheumatol, Seoul 06591, South Korea

来源：

CELLS | 2021年 / 10卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

ubiquitin-conjugating enzyme; cancer; ubiquitination; CELL-CYCLE GENE; BREAST-CANCER; IN-VITRO; UBC13-UEV1A INTERACTION; PROGNOSTIC-SIGNIFICANCE; TUMOR-SUPPRESSOR; CARCINOMA-CELLS; UBE2O PROMOTES; MARINE SPONGE; HUMAN CDC34;

D O I：

10.3390/cells10061383

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)-E2 (conjugating)-E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.

引用

页数：16

共 50 条

[1] Role of the ubiquitin-conjugating enzymes in plant innate immunity
Zeng, L.
Zhou, B.
Mural, R.
Chen, X.
Oates, M.
Connor, R.
Martin, G. B.
Gough, J.
PHYTOPATHOLOGY, 2018, 108 (10) : 9 - 9
[2] The role of ubiquitin-conjugating enzymes during seed germination
Habanova, Hana
Hyskova, Anna
PROCEEDINGS OF 25TH INTERNATIONAL PHD STUDENTS CONFERENCE (MENDELNET 2018), 2018, : 325 - 329
[3] UBIQUITIN-CONJUGATING ENZYMES - NOVEL REGULATORS OF EUKARYOTIC CELLS
JENTSCH, S
SEUFERT, W
SOMMER, T
REINS, HA
TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (05) : 195 - 198
[4] A Subset of Ubiquitin-Conjugating Enzymes Is Essential for Plant Immunity
Zhou, Bangjun
Mural, Ravi V.
Chen, Xuanyang
Oates, Matt E.
Connor, Richard A.
Martin, Gregory B.
Gough, Julian
Zeng, Lirong
PLANT PHYSIOLOGY, 2017, 173 (02) : 1371 - 1390
[5] REDIRECTING THE SPECIFICITY OF UBIQUITINATION BY MODIFYING UBIQUITIN-CONJUGATING ENZYMES
GOSINK, MM
VIERSTRA, RD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9117 - 9121
[6] E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions
Hosseini, Seyed Mohammad
Okoye, Isobel
Chaleshtari, Mitra Ghasemi
Hazhirkarzar, Bita
Mohamadnejad, Javad
Azizi, Gholamreza
Hojjat-Farsangi, Mohammad
Mohammadi, Hamed
Shotorbani, Siamak Sandoghchian
Jadidi-Niaragh, Farhad
CLINICA CHIMICA ACTA, 2019, 498 : 126 - 134
[7] EVIDENCE FOR A PARTICULATE LOCATION OF UBIQUITIN CONJUGATES AND UBIQUITIN-CONJUGATING ENZYMES IN RABBIT BRAIN
MAGNANI, M
SERAFINI, G
ANTONELLI, A
MALATESTA, M
GAZZANELLI, G
JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (31) : 21018 - 21024
[8] A conserved asparagine has a structural role in ubiquitin-conjugating enzymes
Berndsen C.E.
Wiener R.
Yu I.W.
Ringel A.E.
Wolberger C.
Nature Chemical Biology, 2013, 9 (3) : 154 - 156
[9] Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress
JahngenHodge, J
Obin, MS
Gong, X
Shang, F
Nowell, TR
Gong, JX
Abasi, H
Blumberg, J
Taylor, A
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (45) : 28218 - 28226
[10] A conserved asparagine has a structural role in ubiquitin-conjugating enzymes
Berndsen, Christopher E.
Wiener, Reuven
Yu, Ian W.
Ringel, Alison E.
Wolberger, Cynthia
NATURE CHEMICAL BIOLOGY, 2013, 9 (03) : 154 - 156

← 1 2 3 4 5 →