Functional variability of Rev response element in HIV-1 primary isolates

被引：17
|
作者：
Phuphuakrat, A [1 ]
Auewarakul, P [1 ]
机构：
[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand
来源：
VIRUS GENES | 2005年 / 30卷 / 01期
关键词：
HIV-1; RRE; variability;
D O I：
10.1007/s11262-004-4578-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We have previously studied sequence heterogeneity of HIV-1 Rev response element (RRE), and showed uneven variations in different stem-loops of both primary sequence and secondary structure. Here we studied the functional variation of RRE clones from a set of 10 primary isolates, and demonstrated a variation in the function of these RRE clones on the expression of Gag proteins from a truncated HIV-1 genome. The difference in Gag level was, in part, if not exclusively, resulted from the differential efficiency of RNA transport and enhancing of translation. These data suggested that variation of HIV-1 RRE may play a role in regulation of viral replication rate in HIV-1 primary isolates.
引用
收藏
页码：23 / 29
页数：7
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