Non-sentinel lymph node analysis with one-step nucleic acid amplification in breast cancer patients

被引：3
|
作者：
Ogiya, Akiko [1 ]
Iwase, Takuji [1 ]
Kitagawa, Dai [1 ]
Nakashima, Eri [1 ]
Sakai, Takehiko [1 ]
Miyagi, Yumi [1 ]
Iijima, Kotaro [1 ]
Morizono, Hidetomo [1 ]
Makita, Masujiro [1 ]
Horii, Rie [2 ]
Akiyama, Futoshi [3 ]
机构：
[1] Japanese Fdn Canc Res, Canc Inst Hosp, Breast Oncol Ctr, Dept Surg Oncol,Koto Ku, Tokyo 1358550, Japan
[2] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Pathol, Koto Ku, Tokyo 1358550, Japan
[3] Japanese Fdn Canc Res, Inst Canc, Div Pathol, Koto Ku, Tokyo 1358550, Japan
来源：
BREAST | 2015年 / 24卷 / 04期
关键词：
Breast cancer; Whole sentinel lymph node; One-step nucleic amplification assay; Non-sentinel lymph node; AXILLARY DISSECTION; MOLECULAR ASSAY; CLINICAL-TRIAL; METASTASES; CARCINOMA; BIOPSY; UPDATE;
D O I：
10.1016/j.breast.2015.04.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: One-step nucleic acid amplification (OSNA) examines lymph node metastasis in a semi-quantitative manner with molecular biology techniques. In this study, we conducted a whole-node analysis of non-sentinel lymph nodes (SLNs) using the OSNA method in SLN metastasis-positive breast cancer patients. Methods: With the OSNA method, we compared the rates of positivity of non-SLN metastasis in cases with both SLN micro-and macrometastases. Results: The rates of non-SLN metastasis positivity in those with SLN micrometastasis and macrometastasis were 44% and 48%, respectively, and this difference was not significant. When the study of non-SLN metastasis positivity was focused only on macrometastases, the rates of non-SLN metastasis positivity in patients with SLN micrometastasis and macrometastasis were 19% and 22%, respectively, and there was no significant difference. Conclusion: Regardless of the copy number of SLN metastases, non-SLN metastases were found in approximately half of the cases. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：476 / 480
页数：5
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