Synthesis of a tetrasubstituted bicyclo[2.2.2]octane as a potential inhibitor of influenza virus sialidase

被引：14
|
作者：
Smith, PW
Trivedi, N
Howes, PD
Sollis, SL
Rahim, G
Bethell, RC
Lynn, S
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Enzyme Med Chem 2, Stevenage SG1 2NY, Herts, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Enzyme Pharmacol, Stevenage SG1 2NY, Herts, England
[3] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Phys Sci, Stevenage SG1 2NY, Herts, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(99)00033-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel synthesis of the bicycle [2.2.2] octane ring system has been achieved utilising a tandem Henry cyclisation as the key stage. This chemistry has been employed in the synthesis of a potential inhibitor of influenza virus sialidase (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：611 / 614
页数：4
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