Toward production of pure 13C hyperpolarized metabolites using heterogeneous parahydrogen-induced polarization of ethyl[1-13C]acetate

被引：0

作者：

Kovtunov, K. V. ^{[1
,2
]}

Barskiy, D. A. ^{[3
]}

Salnikov, O. G. ^{[1
,2
]}

Shchepin, R. V. ^{[3
]}

Coffey, A. M. ^{[3
]}

Kovtunova, L. M. ^{[2
,4
]}

Bukhtiyarov, V. I. ^{[2
,4
]}

Koptyug, I. V. ^{[1
,2
]}

Chekmenev, E. Y. ^{[3
,5
]}

机构：

[1] Int Tomog Ctr SB RAS, Lab Magnet Resonance Microimaging, Inst Skaya St 3A, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia

[3] Vanderbilt Univ, Inst Imaging Sci VUIIS, Dept Radiol, Dept Biomed Engn,VICC, Nashville, TN 37232 USA

[4] SB RAS, Boreskov Inst Catalysis, 5 Acad Lavrentiev Pr, Novosibirsk 630090, Russia

[5] Russian Acad Sci, Leninskiy Prospect 14, Moscow 119991, Russia

来源：

RSC ADVANCES | 2016年 / 6卷 / 74期

基金：

俄罗斯科学基金会; 美国国家科学基金会;

关键词：

HYDROGEN-INDUCED POLARIZATION; NMR SIGNAL ENHANCEMENT; IN-VIVO; MAGNETIC-RESONANCE; PASADENA HYPERPOLARIZATION; AQUEOUS-PHASE; CATALYST; EXCHANGE; PYRUVATE; WATER;

D O I：

10.1039/c6ra15808k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we report the production of C-13-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of C-13 isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.

引用

页码：69728 / 69732

页数：5

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