Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

被引：36

作者：

Manley, Brett J. ^{[1
,2
,3
]}

Roberts, Robin S. ^{[4
]}

Doyle, Lex W. ^{[1
,3
,5
,6
]}

Schmidt, Barbara ^{[4
,7
,8
]}

Anderson, Peter J. ^{[3
,6
]}

Barrington, Keith J. ^{[9
]}

Bohm, Birgitta ^{[10
]}

Golan, Agneta ^{[11
]}

van Wassenaer-Leemhuis, Aleid G. ^{[12
]}

Davis, Peter G. ^{[1
,2
,3
]}

机构：

[1] Univ Melbourne, Dept Obstet & Gynecol, Melbourne, Vic 3010, Australia

[2] Royal Womens Hosp, Neonatal Serv & Newborn Res Ctr, Parkville, Vic 3052, Australia

[3] Murdoch Childrens Res Inst, Melbourne, Australia

[4] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[5] Royal Hosp Women, Res Off, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia

[7] Univ Penn, Childrens Hosp Philadelphia, Div Neonatol, Philadelphia, PA 19104 USA

[8] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA

[9] McGill Univ, Montreal, PQ, Canada

[10] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

[11] Soroka Med Ctr, IL-84101 Beer Sheva, Israel

[12] Emma Childrens Hosp AMC, Dept Neonatol, Amsterdam, Netherlands

来源：

JOURNAL OF PEDIATRICS | 2015年 / 166卷 / 04期

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

BORN EXTREMELY PRETERM; CAFFEINE THERAPY; SOCIOECONOMIC-STATUS; BAYLEY-III; AGE; PREMATURITY; CHILDHOOD; APNEA; TERM; INTELLIGENCE;

D O I：

10.1016/j.jpeds.2014.12.016

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To determine the extent that social variables influence cognitive development of very low birth weight (VLBW) infants across the preschool years. Study design Participants were VLBW (500-1250 g) children enrolled in the Caffeine for Apnea of Prematurity randomized trial between 1999 and 2004. We investigated the relationships between 4 potential social advantages: higher maternal education, higher paternal education, caregiver employment, and 2 biologic parents in the same home-and gain in cognitive scores. Cognitive assessments were performed at the corrected ages of 18 months (Mental Development Index score on the Bayley Scales of Infant Development II) and 5 years (Full Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence III). Cognitive gain was computed by subtracting each individual 18-month Mental Development Index score from the corresponding Full Scale IQ at 5 years. Results Data were available for 1347 children. Mean (SD) cognitive scores were 90.8 (15.7) at 18 months and 98.9 (14.5) at 5 years. Multivariable regression showed that higher maternal education, higher paternal education, and caregiver employment had independent and additive effects of similar size on cognitive gain (P < .001); the mean cognitive gain between 18 months and 5 years increased by 3.6 points in the presence of each of these advantages. When all 3 were present, cognitive scores improved on average by 10.9 points compared with children without any of these advantages. Conclusion In VLBW children, a count of 3 social advantages strongly predicts gains in cognitive scores across the preschool years.

引用

页码：870 / U158

页数：9