We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. Later on, while the neural crest-derived tissues of the head continue to express endothelin-A receptor, endothelin 1 is no longer expressed in their environment. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
机构:
St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Candlelighters Childrens Canc Res Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Candlelighters Childrens Canc Res Lab, Leeds LS9 7TF, W Yorkshire, England
Berry, PA
Burchill, SA
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St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Candlelighters Childrens Canc Res Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Candlelighters Childrens Canc Res Lab, Leeds LS9 7TF, W Yorkshire, England