The FXR/TGR5 dual agonist INT-767 prevents and reverses Western diet-induced NASH and modulates major lipid metabolic pathways in mice

被引：0
|
作者：
Wang, Xiaoxin [1 ]
Libby, Andrew [1 ]
Ranjit, Suman [2 ]
Wang, Dong [1 ]
Luo, Yuhuan [1 ]
Orlicky, David J. [1 ]
McManaman, James [1 ]
Dobrinskikh, Evgenia [1 ]
Gratton, Enrico [2 ]
Young, Mark [3 ]
Adorini, Luciano [3 ]
Levi, Moshe [1 ]
机构：
[1] Univ Colorado, Aurora, CO USA
[2] Univ Calif Irvine, Irvine, CA USA
[3] Intercept Pharmaceut, New York, NY USA
来源：
HEPATOLOGY | 2016年 / 64卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1528
引用
收藏
页码：761A / 762A
页数：2
相关论文
共 27 条
  • [1] Treatment with the FXR-TGR5 dual agonist INT-767 arrests and reverses progression of NASH in mice fed a Western diet
    Wang, Xiaoxin
    Luo, Yuhuan
    Orlicky, David J.
    Adorini, Luciano
    Levi, Moshe
    HEPATOLOGY, 2015, 62 : 281A - 281A
  • [2] Treatment with the FXR-TGR5 dual agonist INT-767 decreases NAFLD-NASH in mice fed a Western diet
    Wang, Xiaoxin
    Luo, Yuhuan
    Parker, Cherelle
    McMahan, Rachel
    Rosen, Hugo R.
    Orlicky, David J.
    Adorini, Luciano
    Levi, Moshe
    HEPATOLOGY, 2014, 60 : 740A - 740A
  • [3] Detailed Analyses of the Antifibrotic effects of INT-767, a dual FXR/TGR5 agonist, in an obese mouse model of diet-induced and biopsy-confirmed NASH
    Veidal, Sanne Skovgaard
    Feigh, Michael
    Hansen, Henrik B.
    Jelsing, Jacob
    Vrang, Niels
    Petitjean, Matthieu
    Chen, Li
    Young, Mark
    Roth, Jonathan D.
    HEPATOLOGY, 2017, 66 : 1044A - 1044A
  • [4] The dual FXR/TGR5 agonist INT-767 counteracts non-alcoholic steatohepatitis in a rabbit model of high fat diet-induced metabolic syndrome
    Vignozzi, Linda
    Cellai, Ilaria
    Filippi, Sandra
    Comeglio, Paolo
    Sarchielli, Erica
    Morelli, Annamaria
    Maneschi, Elena
    Vannelli, Gabriella Barbara
    Adorini, Luciano
    Maggi, Mario
    HEPATOLOGY, 2015, 62 : 645A - 645A
  • [5] THE DUAL FXR/TGR5 AGONIST INT-767 COUNTERACTS NONALCOHOLIC STEATOHEPATITIS AND ERECTILE DYSFUNCTION IN A RABBIT MODEL OF HIGH FAT DIET-INDUCED METABOLIC SYNDROME
    Vignozzi, L.
    Cellai, I
    Filippi, S.
    Comeglio, P.
    Sarchielli, E.
    Morelli, A.
    Maneschi, E.
    Vannelli, G. B.
    Adorini, L.
    Maggi, M.
    JOURNAL OF SEXUAL MEDICINE, 2017, 14 (04): : E143 - E144
  • [6] The dual FXR/TGR5 agonist INT-767 inhibits nonalcoholic steatohepatitis development in a rabbit model of metabolic syndrome
    Comeglio, Paolo
    Filippi, Sandra
    Cellai, Ilaria
    Maneschi, Elena
    Corcetto, Francesca
    Como, Chiara
    Morelli, Annamaria
    Adorini, Luciano
    Maggi, Mario
    Vianozzi, Linda
    HEPATOLOGY, 2016, 64 : 758A - 759A
  • [7] FXR/TGR5 Dual Agonist INT-767 Reduces NAS & Fibrosis & Improves Plasma & Hepatic Lipid Profiles in the AMLN Mouse Model of Diet-induced & Biopsy-confirmed NASH
    Roth, Jonathan
    Feigh, Michael
    Herrmann, Sibylle
    SWISS MEDICAL WEEKLY, 2017, 147 : 20S - 20S
  • [8] FUNCTIONAL CHARACTERIZATION OF THE SEMI-SYNTHETIC BILE ACID DERIVATIVE INT-767, A DUAL FXR AND TGR5 AGONIST
    Rizzo, Giovanni
    Passeri, Daniela
    De Franco, Francesca
    Ciaccioli, Gianmario
    Donadio, Loredana
    Rizzo, Giorgio
    Orlandi, Stefano
    Sadeghpour, Bahman
    Wang, Xiaoxin
    Jiang, Tao
    Levi, Moshe
    Pruzanski, Mark
    Adorini, Luciano
    HEPATOLOGY, 2010, 52 (04) : 595A - 595A
  • [9] High Milkfat Diet Causes More Severe NASH Compared to High Lard Diet: The Dual FXR-TGR5 Agonist INT-767 Prevents NASH in both Models
    Wang, Xiaoxin
    Luo, Yuhuan
    Orlicky, David J.
    Adorini, Luciano
    Levi, Moshe
    HEPATOLOGY, 2015, 62 : 657A - 657A
  • [10] FUNCTIONAL CHARACTERIZATION OF THE SEMI-SYNTHETIC BILE ACID DERIVATIVE INT-767, A DUAL FXR AND TGR5 AGONIST
    Rizzo, G.
    Passeri, D.
    De Franco, F.
    Ciaccioli, G.
    Sadeghpour, B.
    Pellicciari, R.
    Pruzanski, M.
    Adorini, L.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S430 - S431
123