Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids

被引：43

作者：

Song, Ji-Won ^{[1
]}

Seo, Joo-Hyun ^{[2
]}

Oh, Doek-Kun ^{[3
]}

Bornscheuer, Uwe T. ^{[4
]}

Park, Jin-Byung ^{[1
,5
]}

机构：

[1] Ewha Womans Univ, Dept Food Sci & Engn, Seoul 03760, South Korea

[2] Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Seoul 02707, South Korea

[3] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 143701, South Korea

[4] Greifswald Univ, Inst Biochem, Dept Biotechnol & Enzyme Catalysis, D-17487 Greifswald, Germany

[5] Ewha Womans Univ, Inst Mol Microbiol & Biosyst Engn, Seoul 03760, South Korea

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2020年 / 10卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

RECOMBINANT ESCHERICHIA-COLI; BAEYER-VILLIGER-MONOOXYGENASES; DOUBLE-BOND HYDRATASE; DEEP EUTECTIC SOLVENTS; CYCLOHEXANONE MONOOXYGENASE; ALCOHOL-DEHYDROGENASE; CRYSTAL-STRUCTURE; OLEATE HYDRATASE; PLANT OILS; 3-HYDROXYPROPIONIC ACID;

D O I：

10.1039/c9cy01802f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

One of the key factors to construct a productive whole-cell biocatalytic cascade may include the design of the biotransformation pathways, discovery and engineering of the cascade enzymes, and functional and balanced expression of the cascade enzymes in microbial cells as well as systematic engineering of the whole-cell biocatalytic cascades. Such issues are covered in this review exemplified for the biotransformation of renewable fatty acids into industrially relevant oleochemicals (e.g., medium-chain fatty acids such as n-nonanoic acid, 9-hydroxynonanoic acid, 9-aminononanoic acid, and 1,9-nonanedioic acid) as model systems.

引用

页码：46 / 64

页数：19

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