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Long-QT Syndrome
被引:36
|作者:
Kramer, Daniel B.
[1
]
Zimetbaum, Peter J.
[1
]
机构:
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Div Cardiovasc, Sch Med,Dept Med, Boston, MA 02215 USA
关键词:
long QT syndrome;
sudden cardiac death;
GENOTYPE-PHENOTYPE CORRELATION;
TORSADE-DE-POINTES;
CARDIAC-ARRHYTHMIAS;
MENSTRUAL-CYCLE;
MOLECULAR-BASIS;
LQT2;
FORMS;
HEART-RATE;
EXERCISE;
INTERVAL;
RISK;
D O I:
10.1097/CRD.0b013e3182203504
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Acquired and hereditary long-QT syndromes are important causes of sudden cardiac death. Both categories are characterized by abnormally prolonged cardiac repolarization arising from a complex interaction between genetic and environmental factors. This produces a potentially dangerous substrate for polymorphic ventricular tachycardia and sudden cardiac death. In this review, the pathophysiologic, diagnostic, and prognostic features of long-QT syndromes, as well as recommendations regarding therapy, are reviewed.
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页码:217 / 225
页数:9
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