Synthesis and Investigation of Antimicrobial and Antioxidant Activity of 3-Nitro-N- (3-chloro-2-oxo-substituted-phenyl-azetidin-1-yl)naphtho [2,1-b]furan-2-carboxamides

被引：6

作者：

Devi, K. Shashikala ^{[1
]}

Ramaiah, M. ^{[2
]}

Roopa, D. L. ^{[2
]}

Vaidya, V. P. ^{[3
]}

机构：

[1] Maharanis Sci Coll Women, Dept Chem, Bangalore, Karnataka, India

[2] NMKRV Coll Women, Dept Chem, Bangalore, Karnataka, India

[3] Kuvempu Univ, Dept Chem, Shankaraghatta 577451, Karnataka, India

来源：

E-JOURNAL OF CHEMISTRY | 2010年 / 7卷

关键词：

Azetidinone; Naphthofuran; Antioxidant activity; Antimicrobial activity; BETA-LACTAMS; HETEROCYCLES; MILLENNIUM;

D O I：

10.1155/2010/863547

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ethyl-3-nitronaphtho[2,1-b]furan-2-carboxylate (2) has been synthesized from ethyl naphtha [2,1-b]furan-2-carboxylate (1). This nitro product on reaction with hydrazine hydrate formed 3-nitronaphtho [2,1-b]furan-2-carbohydrazide (3). Various Schiff bases 3-nitro-N-1 (aryl-methylene)-substituted-naphtho [2,1-b]furan-2-carbohydrazides 4(a-g) were obtained by treating hydrazide (3) with different aldehydes. These Schiff bases on reaction with chloro acetyl chloride in presence of triethylamine in dioxane yielded 3-nitro-N-(3-chloro-2-oxo-substituted-phenylazetidine-1-yl)naphtha [2,1-b]furan-2-carboxamides 5(a-g). All the newly synthesized compounds have been characterized by spectral and analytical studies. The Schiff bases, 4a-g and azetidione derivatives, 5a-g have been studied for antioxidant and antimicrobial activities.

引用

页码：S358 / S362

页数：5

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