A direct synthesis of 1-aryl- and 1-alkenylcyclopropylamines from aryl and alkenyl nitriles

被引：64
|
作者：
Bertus, P [1 ]
Szymoniak, J [1 ]
机构：
[1] Univ Reims, CNRS, UMR 6519, F-51687 Reims 2, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 18期
关键词：
D O I：
10.1021/jo034710+
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of various aromatic nitriles with 1.1 equiv of Ti(Oi-Pr)(4) and 2.2 equiv of EtMgBr followed by addition of a Lewis acid gave 1-aryl cyclopropylamines in 43-76% yields. Under similar conditions, conjugated alkene-nitriles afford 1-alkenylcyclopropylamines (42-65%).
引用
收藏
页码：7133 / 7136
页数：4
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