Interferometry measurement of protein concentration evolution during crystallization and dissolution with improved reliability and versatility

被引：11

作者：

Yin, D. C. ^{[1
,2
]}

Inatomi, Y. ^{[3
]}

Luo, H. M. ^{[1
]}

Li, H. S. ^{[1
]}

Lu, H. M. ^{[1
]}

Ye, Y. J. ^{[1
]}

Wakayama, N. I. ^{[4
]}

机构：

[1] Northwestern Polytech Univ, Key Lab Space Biosci & Technol, Xian 710072, Shaanxi, Peoples R China

[2] Northwestern Polytech Univ, Fac Life Sci, Xian 710072, Shaanxi, Peoples R China

[3] JAXA, Inst Space & Astronaut Sci, Space Utilizat Res Ctr, Kanagawa 2298510, Japan

[4] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050003, Japan

来源：

MEASUREMENT SCIENCE AND TECHNOLOGY | 2008年 / 19卷 / 04期

关键词：

concentration; protein concentration; interferometry; Mach-Zehnder interferometer; process in solution; protein crystallization;

D O I：

10.1088/0957-0233/19/4/045303

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Interferometry is a widely used technique for real-time monitoring of concentration variation during processes in a solution like crystal growth and dissolution. This paper reports a protein concentration measurement system using a conventional Mach-Zehnder interferometer that allows monitoring the time course evolution of the protein concentration distribution during the processes of crystallization or dissolution. The demonstrated method showed improved reliability and versatility in that it (1) enables measurements under versatile temperature conditions and (2) eliminates the unpredictable errors caused by the environmental disturbances. The measurement system described in this paper can also be applied in measurements in other solution systems.

引用

页数：8

共 16 条

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[6] CORRECTION FOR VOLUME SHIFT DURING EQUILIBRIUM DIALYSIS BY MEASUREMENT OF PROTEIN-CONCENTRATION
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[8] Improved spectral model building for using ATR-FTIR spectroscopy to measure solution concentration during cooling crystallization
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[9] Real-time measurement of concentration and temperature of solution by two different wavelengths Mach-Zehnder interferometry during crystal growth
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[10] Real-Time Observation of Protein Dense Liquid Cluster Evolution during Nucleation in Protein Crystallization (vol 17, 954958, 2017)
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