Preparation and applications of a polymer-supported phosphoryl azide

被引：22
|
作者：
Lu, YH [1 ]
Taylor, RT [1 ]
机构：
[1] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 52期
关键词：
D O I：
10.1016/j.tetlet.2003.10.066
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A polymer-supported diphenylphosphoryl azide was prepared. This polymer-supported version of DPPA is useful due to its lower toxicity, moisture tolerance and ease of workup after reaction. The synthetic application of this solid-phase reagent was explored by conversion of a variety of carboxylic acids to urethanes and ureas through Curtius rearrangement reactions. Carboxylic acids bearing different functional groups (aromatic, aliphatic and heterocyclic carboxylic acids) were subjected to the reaction. The corresponding products were isolated with satisfactory yields. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：9267 / 9269
页数：3
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