Chronic stress effects on sexual behavior in male and female rats:: Mediation by 5-HT2A receptors

被引:48
|
作者
Gorzalka, BB [1 ]
Hanson, LA [1 ]
Brotto, LA [1 ]
机构
[1] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
wet dog shakes; serotonin; stress; sexual behavior; 5-HT2A receptor; estrogen; progesterone;
D O I
10.1016/S0091-3057(98)00106-3
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of chronic psychosocial stress on sexual behavior and on the serotonergic type 2A (5-HT2A) receptor-mediated behavior "wet dog shakes" (WDS) were investigated in male and female rats. In Experiment 1, both bilaterally adrenalectomized and sham-adrenalectomized female rats were assigned to either a psychosocial stress condition or a control condition for 62 days. On the 63rd day, estrogen-primed females were compared on measures of sexual behavior and WDS. Immediately after the behavioral tests, the same rats were primed with a subthreshold level of progesterone. Three hours after the administration of progesterone, rats were again scored for sexual behavior and WDS. Psychosocial stress was found to facilitate sexual behavior and increase WDS in sham-adrenalectomized female rats providing they were primed with both estrogen and progesterone. In Experiment 2, intact male rats were assigned to either the psychosocial stress condition or the central condition for 30 days. On the 31st day, males were compared on measures of sexual behavior and WDS. No significant differences were revealed on the spontaneous expression of sexual behavior and WDS. Subsequently, males were retested following the administration of the 5-HT2A agonist, DOI. Psychosocial stress resulted in a significant decrease in male sexual behavior and a concurrent increase in WDS, following the administration of DOI. Taken together, these results suggest that chronic psychosocial stress facilitates female sexual behavior and inhibits male sexual behavior, and that the effects of stress on sexual behavior may be mediated by 5-HT2A receptor activity. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:405 / 412
页数:8
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