Canine Pemphigus Foliaceus with Concurrent Immune-Mediated Thrombocytopenia

被引:5
|
作者
Kawarai, Shinpei [1 ]
Hisasue, Masaharu [2 ]
Matsuura, Shinobu [5 ]
Ito, Tetsuro [1 ]
Inoue, Yukari [2 ]
Neo, Sakurako [2 ]
Fujii, Yoko [3 ]
Madarame, Hiroo [1 ]
Shirota, Kinji [4 ]
Tsuchiya, Ryo [2 ]
机构
[1] Azabu Univ, Vet Teaching Hosp, Lab Small Anim Clin, Chuo Ku, Sagamihara, Kanagawa, Japan
[2] Azabu Univ, Lab Vet Internal Med 2, Chuo Ku, Sagamihara, Kanagawa, Japan
[3] Azabu Univ, Lab Vet Surg 1, Chuo Ku, Sagamihara, Kanagawa, Japan
[4] Azabu Univ, Lab Vet Pathol, Dept Vet Med, Chuo Ku, Sagamihara, Kanagawa, Japan
[5] Boston Univ, Sch Med, Ctr Adv Biomed Res, Boston, MA 02118 USA
关键词
SKIN DISEASES; DOGS; ANTIBODIES; ANIMALS;
D O I
10.5326/JAAHA-MS-6044
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A 3 yr old wirehaired fox terrier was presented to his primary care veterinarian with fever, thrombocytopenia, and generalized crusting dermatitis. The skin lesion had progressed for at least 18 days, and thrombocytopenia had developed 3 days before presentation. Histopathology and direct immunofluorescence studies of the skin were consistent with pemphigus foliaceus (PF). Immunofluorescence revealed immunoglobulin G deposition around the keratinocytes in the stratum spinosum. A diagnosis of immune-mediated thrombocytopenia (IMT) was confirmed by the presence of platelet surface-associated immunoglobulin using flow cytometry. Systemic immunosuppressive therapy with cyclosporine and azathioprine was effective, and the dog survived for >2 years from the initial presentation. IMT is rarely associated with PF. This appears to be the first detailed report of a definitive diagnosis of concurrent PF and IMT in a dog. The authors' findings indicate that canine PF could be complicated by hematologic immune-mediated diseases such as IMT.
引用
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页码:56 / 63
页数:8
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