Ultrasound-Triggered Smart Drug Release from Multifunctional Core-Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

被引：119
|
作者：
Jing, Yujia [1 ]
Zhu, Yihua [1 ]
Yang, Xiaoling [1 ]
Shen, Jianhua [1 ]
Li, Chunzhong [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
来源：
LANGMUIR | 2011年 / 27卷 / 03期
基金：
中国国家自然科学基金;
关键词：
SURFACTANT-FREE; DELIVERY; NANOPARTICLES; ENCAPSULATION; MICROCAPSULES; MICROSPHERES; LUMINESCENT; TEMPERATURE; EMULSIONS;
D O I：
10.1021/la1042734
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multifunctional core-shell capsules that triggered release by ultrasound stimulus were one-step fabricated by the coaxial electrospray method. The TiO2 shell suppressed the initial burst release of the paclitaxel. Fe3O4 and graphene quantum dots inside the oil core functioned successfully for magnetic targeting and fluorescence imaging, respectively. Paclitaxel was trigger released when the dual layer of titania shell cracked under the ultrasound stimulation, and the releasing profile could be controlled by the length of applied ultrasound time.
引用
收藏
页码：1175 / 1180
页数：6
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