Direct Analysis of Exhaled Breath of Chronic Hepatitis B Patients by Extractive Electrospray Ionization Mass Spectrometry

被引：0
|
作者：
Wang Hai-Dong [1 ]
Luo Jiao [2 ]
Li Peng-Hui [1 ]
Zhu Lan-Lan [2 ]
Zhang Wei [2 ]
Wu Xiao-Ping [2 ]
Zeng Qian [1 ]
Ding Jian-Hua [1 ]
机构：
[1] E China Inst Technol, Jiangxi Key Labor Atory Mass Spectrometry & Instr, Nanchang 330013, Jiangxi, Peoples R China
[2] NanChang Univ, Affiliated Hosp 1, Nanchang 330123, Jiangxi, Peoples R China
来源：
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2015年 / 43卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Chronic hepatitis B; Exhaled breath; Extractive electrospray ionization mass spectrometry; Principal component analysis; Cluster analysis; LIVER;
D O I：
10.11895/j.issn.0253-3820.140954
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The exhaled breath samples of patients with chronic hepatitis B (41 cases) and healthy volunteers (34 cases) were detected by extractive electrospray ionization mass spectrometry (EESI-MS). After the process of MS data using principal component analysis (PCA) methods, the patients and normal subjects were distinguished effectively, and the PCA results were also validated for cluster analysis (CA). The results are helpful to the analysis of progression of chronic hepatitis B, and may provide bases for the development of a simple, rapid and noninvasive chnical diagnosis method for chronic hepatitis B.
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收藏
页码：507 / 512
页数：6
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