Differences in Biomarkers Pattern Between Severe Isolated Right and Left Ventricular Dysfunction After Cardiac Surgery

Objective: To find out if there are any differences in biomarkers between severe isolated right ventricular (RV) dysfunction and severe isolated left ventricular (LV) dysfunction after cardiac surgery using cardiopulmonary bypass. Design: Observational study. Setting: Teaching hospital. Participants: A total of 46 patients who had severe isolated RV or LV dysfunction after cardiac surgery. Intervention: The authors collected perioperative clinical and biomarker data. Measurements and Main Results: Severe isolated RV dysfunction patients (n = 20) had higher postoperative direct bilirubin (p = 0.030), total bilirubin (p = 0.044), glucose (p = 0.011), and international normalized ratio (INR) (p = 0.050) by repeated measure analysis of variance when com- pared with patients with severe isolated LV dysfunction (n = 26). The RV group also showed lower preoperative alanine transferase (19.3 +/- 1.5 v 32.7 +/- 4.2, p = 0.001), higher 4-hour INR (1.5 +/- 0.3 v 1.4 +/- 0.2, p = 0.008), and higher 48-hour INR (1.8 +/- 0.4 v 1.4 +/- 0.1, p < 0.001). None in the LV group died, whereas 4 patients in the RV group died (all of them had preoperative atrial fibrillation and underwent double valve replacement surgery). Conclusion: The authors observed biomarkers differences between severe isolated RV dysfunction and severe isolated RV dysfunction. (C) 2019 Elsevier Inc. All rights reserved.