2,3-disubstituted benzo[b]thiophenes from diarylalkynes via electrophilic addition-cyclization and palladium-catalyzed cross-coupling

被引：19

作者：

Lamanna, Giuseppe ^{[1
]}

Menichetti, Stefano ^{[1
]}

机构：

[1] Univ Florence, Lab Progettaz Sintesi & Studio Eterocicli Biol At, I-50019 Sesto Fiorentino, FI, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 13期

关键词：

benzo[b]thiophenes; cross-coupling; electrophilic addition; electrophilic substitution; phthalimidesulfenyl chloride; solid phase synthesis; DIRECTED THROMBIN INHIBITORS; ONE-POT SYNTHESIS; ARYL; DERIVATIVES; ANTIESTROGENS; PRECATALYST; CHLORIDES; NHC;

D O I：

10.1002/adsc.200700172

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Diarylalkynes are readily transformed in 3-chlorobenzo[b]thiophenes in a two-step electrophilic addition-cyclization procedure that runs highly efficiently in solution or in the solid phase. The heteroaromatic carbon-chlorine bond participates in palladium-catalyzed Suzuki-Miyaura or Buchwald-Hartwig cross-couplings to give, in a single step, 2,3-disubstituted derivatives of pharmacological relevance.

引用

页码：2188 / 2194

页数：7

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