4-Piperidones from enantiomerically pure enones. Synthesis of 6-alkylsubstituted 4-oxo-pipecolic acid derivatives

被引：2

作者：

Galley, G ^{[1
]}

Ziemer, B ^{[1
]}

Patzel, M ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-10115 Berlin, Germany

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1998年 / 340卷 / 06期

关键词：

D O I：

10.1002/prac.19983400608

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The cyclization of the enantiomerically pure alpha,beta-unsaturated ketone 1, an aliphatic aldehyde 3 and ammonia or benzylamine gives diastereoselectively cis-piperidones 4/4'. Although only modest yields were obtained, the presented cyclization has the advantage of being a single step reaction. The products 4 can serve as precursors for all-cis-4-hydroxypiperidones 5 and novel pipecolic acid derivatives 9.

引用

页码：551 / 556

页数：6

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