A synthesis of the C1-C9 fragment of ionomycin using cationic η3-allylicmolybdenum and -iron complexes

被引：4

作者：

Cooksey, J

Kocienski, P ^{[1
]}

Li, YF

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2005年 / 70卷 / 10期

关键词：

ionophores; antibiotics; pi-allyl complexes; molybdenum; iron; cuprates; total synthesis; stereoselective alkylations;

D O I：

10.1135/cccc20051653

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A key step in the synthesis of the C1-C9 fragment of the ionophore antibiotic ionomycin involves the addition of an alkylcopper(I) reagent to an ester-functionalised cationic eta(3)-allylicmolybdenum and an alkylzinc cuprate to the corresponding eta(3)-allyliciron complex. The reaction is regioselective and the metal directs enantiofacial attack (anti). The stereochemistry of the reactions is proven by an independent synthesis.

引用

页码：1653 / 1668

页数：16

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