Local response prediction in model-based CT material decomposition

Spectral CT is an emerging modality that permits material decomposition and density estimation through the use of energy-dependent information in measurements. Direct model-based material decomposition algorithms have been developed that incorporate statistical models and advanced regularization schemes to improve density estimates and lower exposure requirements. However, understanding and control of the relationship between regularization and image properties is complex with interactions between spectral channels and material bases. In particular, regularization in one material basis can affect the image properties of other material bases, and vice versa. In this work, we derived a closed-form set of local impulse responses for the solutions to a general, regularized, model-based material decomposition (MBMD) objective. These predictors quantify both the spatial resolution in each material image as well as the influence of regularization of one material basis on other material images. This information can be used prospectively to tune regularization parameters for specific imaging goals.