An evolutionary computational approach to the phase problem in macromolecular X-ray crystallography

被引：11

作者：

Webster, G ^{[1
]}

Hilgenfeld, R ^{[1
]}

机构：

[1] Inst Mol Biotechnol, Dept Struct Biol & Crystallog, D-07745 Jena, Germany

来源：

ACTA CRYSTALLOGRAPHICA SECTION A | 2001年 / 57卷

关键词：

D O I：

10.1107/S0108767301000496

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ab initio computation of the molecular envelopes of two proteins exclusively from their corresponding diffraction amplitudes demonstrates that an efficient and inherently parallel evolutionary search algorithm can assist in the direct phasing of macromolecules for which almost no a priori structural information is available. The applicability of this evolutionary computational approach is general and should not be limited to the examples described nor to extremes of data resolution, symmetry or structural size.

引用

页码：351 / 358

页数：8

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