Highly anti-selective asymmetric nitro-Mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors

被引：146
|
作者：
Wang, Chun-Jiang [1 ]
Dong, Xiu-Qin [1 ]
Zhang, Zhi-Hai [1 ]
Xue, Zhi-Yong [1 ]
Teng, Huai-Long [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 27期
关键词：
D O I：
10.1021/ja803538x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly anti-selective and enantioselective nitro-Mannich reactions have been achieved for a broad spectrum of substrates catalyzed by chiral bifunctional multiple hydrogen-bonding-donor amine-thioureas. Multiple hydrogen-bonding donors play a significant role in accelerating reactions and improving yields, diastereoselectivities, and enantioselectivities.
引用
收藏
页码：8606 / +
页数：3
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