P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer

被引：42

作者：

Wirtz, PW

Lang, B

Graus, F

van den Maagdenberg, AMJM

Saiz, A

Gans, PAD

Twijnstra, A

Verschuuren, JJGM

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] John Radcliffe Hosp, Weatherall Inst Mol Med, Dept Neurosci, Oxford OX3 9DS, England

[3] Univ Barcelona, Hosp Clin, Serv Neurol, E-08036 Barcelona, Spain

[4] Leiden Univ, Med Ctr, Ctr Human & Clin Genet, NL-2333 AL Leiden, Netherlands

[5] Univ Hosp Maastricht, Dept Neurol, NL-6202 AZ Maastricht, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 164卷 / 1-2期

关键词：

P/Q-type calcium channel antibody; Lambert-Eaton myasthenic syndrome; paraneoplastic cerebellar degeneration; small cell lung carcinoma; survival;

D O I：

10.1016/j.jneuroim.2005.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To assess the survival impact of the presence of P/Q-type calcium channel antibodies in patients with small cell lung carcinoma (SCLC), we examined the frequency of the antibodies and Lambert-Eaton myasthenic syndrome (LEMS) in 148 consecutive patients with SCLC, and in 30 patients with paraneoplastic cerebellar degeneration and SCLC, and studied their relation with survival. In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：161 / 165

页数：5

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