RARE CIRCULATING TUMOR CELLS ISOLATION VIA SPIRAL-DEFORMED MICROFLUIDIC CHIP

被引：0
|
作者：
Gou, Yixing [1 ,2 ]
Ren, Dahai [2 ]
You, Zheng [2 ]
Sun, Changku [1 ]
Wang, Peng [1 ]
机构：
[1] Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin, Peoples R China
[2] Tsinghua Univ, Dept Precis Instrument, State Key Lab Precis Measuring Technol & Instrume, Beijing, Peoples R China
来源：
2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) | 2019年
关键词：
Circulating tumor cells isolation; inertial microfluidics; particle manipulation; lab-on-a-chip; BLOOD;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
This paper presents a novel spiral-deformed inertial microfluidic system to capture circulating tumor cells (CTCs) from the whole blood with high recovery rate and purity. In this chip, a 5-loop spiral channel and multiple expansion structures were designed to improve the separation performance of the spiral microfluidics based on theoretical modeling and simulations. Experiment results showed that the CTCs' recovery rate is over 90% and the purity can reach about 35%, much higher than conventional spiral microfluidics. This chip has potential to serve as a platform for cancer diagnostics analysis.
引用
收藏
页码：2286 / 2289
页数：4
相关论文
共 50 条
  • [1] Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
    Chen, Hongmei
    Han, Yufeng
    Li, Qingli
    Zou, Yong
    Wang, Shuangshou
    Jiao, Xiaodong
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2023, (200):
  • [2] An integrated microfluidic chip for one-step isolation of circulating tumor cells
    Lee, Tae Yoon
    Hyun, Kyung-A
    Kim, Seung-Il
    Jung, Hyo-Il
    SENSORS AND ACTUATORS B-CHEMICAL, 2017, 238 : 1144 - 1150
  • [3] Thermophoretic isolation of circulating tumor cells, numerical simulation and design of a microfluidic chip
    Asiaei, Sasan
    Darvishi, Vahid
    Davari, Mohammad Hossein
    Zohrevandi, Delaram
    Moghadasi, Hesam
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2019, 137 (03) : 831 - 839
  • [4] Thermophoretic isolation of circulating tumor cells, numerical simulation and design of a microfluidic chip
    Sasan Asiaei
    Vahid Darvishi
    Mohammad Hossein Davari
    Delaram Zohrevandi
    Hesam Moghadasi
    Journal of Thermal Analysis and Calorimetry, 2019, 137 : 831 - 839
  • [5] Integrated Microfluidic Chip for Efficient Isolation and Deformability Analysis of Circulating Tumor Cells
    Liu, Zongbin
    Chen, Rui
    Li, Ying
    Liu, Jianqiao
    Wang, Ping
    Xia, Xuefeng
    Qin, Lidong
    ADVANCED BIOSYSTEMS, 2018, 2 (10)
  • [6] Two-stage microfluidic chip for selective isolation of circulating tumor cells (CTCs)
    Hyun, Kyung-A
    Lee, Tae Yoon
    Lee, Su Hyun
    Jung, Hyo-Il
    BIOSENSORS & BIOELECTRONICS, 2015, 67 : 86 - 92
  • [7] Accurate Isolation of Circulating Tumor Cells via a Heterovalent DNA Framework Recognition Element-Functionalized Microfluidic Chip
    Liu, Yan
    Lin, Zhun
    Zheng, Ziwei
    Zhang, Yuanqing
    Shui, Lingling
    ACS SENSORS, 2022, 7 (02) : 666 - 673
  • [8] Design of a microfluidic chip for enrichment of circulating tumor cells
    Department of Precision Instrument, Tsinghua University, Beijing
    100084, China
    Key Eng Mat, (1320-1325):
  • [9] Analytical Validation of a Spiral Microfluidic Chip with Hydrofoil-Shaped Pillars for the Enrichment of Circulating Tumor Cells
    Sen-Dogan, Begum
    Demir, Mehmet Alper
    Sahin, Buket
    Yildirim, Ender
    Karayalcin, Gizem
    Sahin, Sebnem
    Mutlu, Ege
    Toral, Taylan Berkin
    Ozgur, Ebru
    Zorlu, Ozge
    Kulah, Haluk
    BIOSENSORS-BASEL, 2023, 13 (10):
  • [10] Microfluidic platform for circulating tumor cells isolation and detection
    Zhang, Jiahao
    Ren, Jie
    LI, Zirui
    Gou, Yixing
    BIOCELL, 2023, 47 (07) : 1439 - 1447
12345