Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation

被引：0
|
作者：
Liu, Yang [1 ,2 ,3 ]
Jia, Yunbo [1 ]
Lv, Jing [2 ]
Sun, Dan [2 ]
Yin, Yalei [2 ]
Liu, Nan [4 ]
Su, Benli [4 ]
Sun, Guangwei [1 ,2 ]
机构：
[1] China Med Univ, Innovat Engn Technol Res Ctr Cell Therapy, Shengjing Hosp, Shenyang 110022, Peoples R China
[2] Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[3] China Med Univ, Lab Canc Metab, Shengjing Hosp, Shenyang 117004, Peoples R China
[4] Dalian Med Univ, Hosp 2, Dalian 116023, Peoples R China
来源：
STEM CELL RESEARCH | 2022年 / 61卷
关键词：
GLY40SER MUTATION; GENE;
D O I：
10.1016/j.scr.2022.102745
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Induced pluripotent stem cell (iPSC) line, SJHi001-A, was generated from a diabetic patient carrying a heterozygous c.G248A mutation in GCGR gene that generated the p.W83X. The PBMCs from her father (no diabetes and no mutation site) were also prepared into iPSC (SJHi002-A) as a control. Both two cell lines had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo.
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页数：4
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