Effect of antidigoxin monoclonal antibodies on cardiac disturbances caused by high concentrations of digoxin

被引：0
|
作者：
Pokid'ko, YN [1 ]
Isaeva, SA [1 ]
Mnasina, EE [1 ]
Danilova, NP [1 ]
Vasilov, RG [1 ]
机构：
[1] Inst Biotechnol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 125卷 / 06期
关键词：
monoclonal antibodies; digoxin; Na; K-ATPase;
D O I：
10.1007/BF02445255
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Effect of high-affinity mouse monoclonal antidigoxin antibodies D22 on digoxin-induced cardiac disturbances is studied in guinea pigs injected with 0.5 mg/kg digoxin. Five minutes after digoxin injection, bradycardia, isolated extrasystoles, conduction disturbances, and changes in the ST segment and QRS complex appear; digoxin concentration attains 0.2-0.4 mu g/ml. Antidigoxin monoclonal antibodies injected 10 min after digoxin slightly reduce heart rate, prevent isolated extrasystoles, improve atrioventricular conduction, and normalize the amplitude of the ST segment and the shape of the QRS complex. Serum digoxin concentration decreases to 0.015-0.03 mu g/ml. These data suggest that monoclonal antidigoxin antibodies can be effectively used in acute digoxin intoxication.
引用
收藏
页码：612 / 615
页数：4
相关论文
共 50 条
  • [1] Effect of antidigoxin monoclonal antibodies on cardiac disturbances caused by high concentrations of digoxin
    Yu. N. Pokid'ko
    S. A. Isaeva
    E. E. Mnasina
    N. P. Danilova
    R. G. Vasilov
    Bulletin of Experimental Biology and Medicine, 1998, 125 : 612 - 615
  • [2] IMMOBILIZED MONOCLONAL ANTIDIGOXIN ANTIBODIES FOR THE REMOVAL OF DIGOXIN FROM PLASMA
    ROLLINS, DE
    BRIZGYS, M
    PINCUS, S
    VETERINARY AND HUMAN TOXICOLOGY, 1986, 28 (05) : 498 - 498
  • [3] REMOVAL OF DIGOXIN FROM PLASMA USING MONOCLONAL ANTIDIGOXIN ANTIBODIES IMMOBILIZED ON AGAROSE
    BRIZGYS, M
    PINCUS, S
    ROLLINS, DE
    FEDERATION PROCEEDINGS, 1986, 45 (06) : 1576 - 1576
  • [4] MONOCLONAL ANTIDIGOXIN ANTIBODIES - PREPARATION, CHARACTERIZATION AND STUDIES OF MECHANISM AND APPLICATION OF REVERSING DIGOXIN TOXICITY
    JIN, JP
    WANG, MX
    ZHANG, NZ
    WANG, JZ
    JIN, BQ
    HYBRIDOMA, 1987, 6 (02): : 232 - 232
  • [5] HIGH-AFFINITY MONOCLONAL-ANTIBODIES TO THE CARDIAC GLYCOSIDE, DIGOXIN
    HUNTER, MM
    MARGOLIES, MN
    JU, A
    HABER, E
    JOURNAL OF IMMUNOLOGY, 1982, 129 (03): : 1165 - 1172
  • [6] NOVEL ANTIDIGOXIN MONOCLONAL-ANTIBODIES WITH DIFFERENT BINDING SPECIFICITIES FOR DIGOXIN METABOLITES AND OTHER GLYCOSIDES
    WAHYONO, D
    PIECHACZYK, M
    MOURTON, C
    BASTIDE, JM
    PAU, B
    HYBRIDOMA, 1990, 9 (06): : 619 - 629
  • [7] SPECIFIC REMOVAL OF DIGOXIN FROM GUINEA-PIGS USING MONOCLONAL ANTIDIGOXIN ANTIBODIES IMMOBILIZED ON AGAROSE
    BRIZGYS, M
    PINCUS, S
    ROLLINS, DE
    FEDERATION PROCEEDINGS, 1987, 46 (04) : 1137 - 1137
  • [8] SPECIFICITY OF SELECTED HIGH-AFFINITY ANTIDIGOXIN MONOCLONAL-ANTIBODIES
    TYUTYULKOVA, SN
    KEHAYOV, IR
    KYURKCHIEV, SD
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1990, 43 (08): : 137 - 140
  • [9] EFFECT OF FAB FRAGMENTS OF SHEEP ANTIDIGOXIN ANTIBODY (DIB AB) ON SERUM CONCENTRATIONS AND URINARY-EXCRETION OF DIGOXIN (DIG)
    BUTLER, VP
    SCHMIDT, DH
    SMITH, TW
    HABER, E
    RAYNOR, BD
    DEMARTIN.P
    CIRCULATION, 1973, 48 (04) : 130 - 130
  • [10] EFFECT OF QUINIDINE ON THE RENAL CLEARANCE OF DIGOXIN IN THE PRESENCE OF LOW AND HIGH SERUM DIGOXIN CONCENTRATIONS
    CLOHISY, DR
    QUINTANILLA, AP
    GIBSON, TP
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1982, 222 (01): : 49 - 51
12345