An innovative nanoprobe for magnetic immunoassay: Individual γ-Fe2O3 nanoparticles; towards high sensitive and multiparametric detection

被引:2
|
作者
de Montferrand, C. [1 ,2 ]
Milosevic, I. [1 ]
Jouni, H. [1 ]
Lievre, N. [3 ]
Lalatonne, Y. [1 ,4 ]
Motte, L. [1 ]
机构
[1] Univ Paris 13, Lab CSPBAT, CNRS, UMR 7244, F-93017 Bobigny, France
[2] Magnisense, F-75008 Paris, France
[3] UPRES 3410, F-93017 Bobigny, France
[4] Hop Avicenne, Nucl Med Serv, F-93017 Bobigny, France
关键词
IRON-OXIDE NANOPARTICLES; SIGNATURES; RECEPTORS;
D O I
10.1016/j.irbm.2011.09.004
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A new type of nanolabels for magnetic immunoassays was designed using individual superparamagnetic gamma-Fe2O3 nanoparticles. This innovative candidate is confronted here with commonly used micrometric beads. The innovative MIAplex (R) technology allows to characterize and to quantify both types of labels with a competitive limit of detection. In this paper, we demonstrate the feasibility of multiparametric immunotests with the MIAplex (R) technology. The carboxylic functions at the outer particle surface act as a precursor group for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:302 / 305
页数:4
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