Exaggerated serotonin-mediated platelet reactivity as a possible link in depression and acute coronary syndromes

被引：85
|
作者：
Shimbo, D
Child, J
Davidson, K
Geer, E
Osende, JI
Reddy, S
Dronge, A
Fuster, V
Badimon, JJ
机构：
[1] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, Cardiovasc Biol Res Lab, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Div Gen Internal Med, New York, NY 10029 USA
[3] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 03期
关键词：
D O I：
10.1016/S0002-9149(01)02236-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Depressive illness increases the risk of first acute coronary syndrome events, but the underlying mechanisms remain undetermined. Our finding that serotonin-mediated platelet reactivity was significantly higher in depressed patients relative to nondepressed controls suggests that the association between depression and acute coronar), syndromes is related to increased serotonin-mediated platelet reactivity.
引用
收藏
页码：331 / +
页数：4
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