A lateral flow assay for simultaneous detection of Deoxynivalenol, Fumonisin B1 and Aflatoxin B1

被引：44
|
作者：
Yu, Songcheng [1 ]
He, Leiliang [1 ]
Yu, Fei [1 ]
Liu, Lie [1 ]
Qu, Chenling [3 ]
Qu, Lingbo [2 ]
Liu, Jie [1 ]
Wu, Yuming [1 ]
Wu, Yongjun [1 ,2 ]
机构：
[1] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ, Henan Joint Int Res Lab Green Construct Funct Mol, Zhengzhou 450001, Henan, Peoples R China
[3] Henan Univ Technol, Coll Grain Oil & Food Sci, Zhengzhou 450052, Henan, Peoples R China
来源：
TOXICON | 2018年 / 156卷
基金：
中国国家自然科学基金;
关键词：
Deoxynivalenol; Fumonisin B-1; Aflatoxin B-1; Lateral flow assay; Food safety; PHOTOLUMINESCENCE IMMUNOSENSOR;
D O I：
10.1016/j.toxicon.2018.10.305
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Deoxynivalenol (DON), Fumonisin B-1 (FB1) and Aflatoxin B1 (AFB(1)) have strong toxicity to humans and exist widely in grain and food. It is necessary to screen these mycotoxins to guarantee food safety. In order to develop a rapid, simple, low-cost and simultaneous-detection method, composites of antibody-nano-Au-particles, DON-BSA, FB1-BSA, and AFB(1)-BSA were prepared to establish a lateral flow assay based on competitive inhibition. The results suggested that the visual detection limits for DON, FB1 and AFB(1) were 10, 30, and 10 ng mL(-1), respectively. On the other hand, it had no reactivity to T-2 toxin, zearalenone, ochratoxin A and nivalenol, which demonstrates good specificity. Besides, the strip had good repeatability and stability. Therefore, DON, FB1 and AFB(1) would be screened simultaneously by lateral flow assay for food safety.
引用
收藏
页码：23 / 27
页数：5
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