Stereoselective synthesis of 4-substituted 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

被引：4

作者：

Golantsov, NE

Karchava, AV

Nosova, VM

Yurovskaya, MA

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

[2] State Sci Ctr Russian Fed, State Res Inst Chem Technol Organoelement Cpds, Moscow 111123, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2005年 / 54卷 / 01期

关键词：

1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles; 1,2,3,4-tetrahydropyrazino[1,2-a]indoles; N-substituted indoles; reduction of nitrites; 2-cyanoindole; Mitsunobu reaction;

D O I：

10.1007/s11172-005-0241-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Substituted 1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized from 2-cyano-indole. (R)-4-Methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole was obtained by the Mitsunobu reaction. Stereoselective reduction of 4-substituted 1,2,3,4-tetrahydropyrazino[1,2-a]indoles gave 4-substituted 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles. (4R,10aR)-4-Methyl-1,2,3,4, 10, 10a-hexahydropyrazino[1,2-a]indole was synthesized.

引用

页码：226 / 230

页数：5

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