Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages

被引：66

作者：

Ferguson, J. Scott

Martin, Jennifer L.

Azad, Abul K.

McCarthy, Travis R.

Kang, Peter B.

Voelker, Dennis R.

Crouch, Erika C.

Schlesinger, Larry S.

机构：

[1] Ohio State Univ, Dept Internal Med, Div Infect Dis, Ctr Microbial Interface Biol, Columbus, OH 43210 USA

[2] Univ Iowa, Iowa City, IA 52242 USA

[3] Iowa City Vet Affairs Med Ctr, Dept Med, Div Pulm & Crit Care Med, Iowa City, IA 52242 USA

[4] Iowa City Vet Affairs Med Ctr, Dept Med, Div Infect Dis, Iowa City, IA 52242 USA

[5] Iowa City Vet Affairs Med Ctr, Dept Microbiol, Iowa City, IA 52242 USA

[6] Natl Jewish Ctr Immunol & Resp Med, Dept Med, Lord & Taylor Lab Lung Biochem, Denver, CO 80206 USA

[7] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 12期

关键词：

D O I：

10.1128/IAI.01402-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.

引用

页码：7005 / 7009

页数：5

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