Surface Biomodification of Surgical Meshes Intended for Hernia Repair

The article presents a method of producing a composite surgical mesh. A synthetic, macroporous mesh with mechanical properties similar to that of the abdominal wall and with reduced surface density compared to conventional surgical meshes was made of polypropylene (PP) monofilament. The mesh was used as a substrate for a layer of modified bacterial cellulose (MBC) produced by a microbial synthesis with the use of the Acetobacter xylinum strain. The PP mesh was coated with the MBC layer directly in the process of biosynthesis in liquid culture medium with the addition of chitosan modifier. During the resorption process, under the action of body enzymes, amino sugars are released from the MBC layer, which have the ability to stimulate tissue granulation and accelerate the wound healing process, while preventing formation of scars.