Development of Imidazo[1,2-a]pyridine-based probe for detection of hydrazine and its applications in imaging of HepG2 cell

被引：20
|
作者：
Li, Dan [1 ]
Wang, Qin [1 ]
Rao, Nian [1 ]
Zhang, Yan [1 ]
Le, Yi [1 ,2 ]
Liu, Li [1 ,2 ]
Li, Luolan [3 ]
Huang, Lei [4 ,5 ,6 ]
Yan, Longjia [1 ,2 ,4 ]
机构：
[1] Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China
[2] Guizhou Univ, Guizhou Engn Lab Synthet Drugs, Guiyang 550025, Peoples R China
[3] Guizhou Univ Tradit Chinese Med, Shizhen Coll, Guiyang 550025, Peoples R China
[4] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China
[5] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China
[6] Chinese Acad Sci, Guiyang 550014, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2021年 / 1239卷 / 1239期
关键词：
Imidazo[1,2-a]pyridine; Fluorescence; Probe; Hydrazine; Hepg2; cell; RATIOMETRIC FLUORESCENT-PROBE; SENSITIVE DETECTION; LIVING CELLS; SENSOR; ESIPT;
D O I：
10.1016/j.molstruc.2021.130521
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel fluorescent probe IMPD based on imidazo[1,2-a]pyridine for detection of hydrazine was designed and synthesized. This probe used maleimide as the recognition group, which was rapid and sensitive for hydrazine. To compare with our previous probe for hydrazine, this newly probe showed a lower detection limit for 9.1 ppb. In addition, the probe IMPD could dye the HepG2 cell with blue color at the presence of hydrazine. (C) 2021 Elsevier B.V. All rights reserved.
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页数：6
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