A 'natural' mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1)

被引：111

作者：

Gaisne, M ^{[1
]}

Bécam, AM ^{[1
]}

Verdière, J ^{[1
]}

Herbert, CJ ^{[1
]}

机构：

[1] Univ Paris 06, Ctr Genet Mol, CNRS, Lab Propre, F-91198 Gif Sur Yvette, France

来源：

CURRENT GENETICS | 1999年 / 36卷 / 04期

关键词：

Saccharomyces cerevisiae; HAP1/CYP1; S288c; Ty1;

D O I：

10.1007/s002940050490

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The HAP1 gene encodes a complex transcriptional regulator of many genes involved in electron-transfer reactions and is essential in anaerobic or heme-depleted conditions. We show here that strains derived from S288c carry a defective Ty1 element inserted in the 3' region of the HAP1 ORF. This mutant allele acts as a HAP1 null allele in terms of cytochrome c expression and CYC1 UAS1-dependent transcription, but is able to sustain limited growth in heme-depleted conditions.

引用

页码：195 / 200

页数：6

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