Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement

被引：72
|
作者：
Bao, Hongli [1 ]
Tambar, Uttam K. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Div Chem, Dallas, TX 75390 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 45期
基金：
美国国家卫生研究院;
关键词：
C-H AMINATION; BONDS; AMIDATION; INSIGHTS; ALKENES; REARRANGEMENT; DIAMINATION; ACETYLENES; ACTIVATION; CARBON;
D O I：
10.1021/ja307851b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective allylic am nation. of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen. containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement.
引用
收藏
页码：18495 / 18498
页数：4
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