Effects of rat medial prefrontal cortex temporal inactivation on a delayed alternation task

被引：40
|
作者：
Izaki, Y
Maruki, K
Hori, K
Nomura, M
机构：
[1] Saitama Med Sch, Dept Physiol, Iruma, Saitama 3500495, Japan
[2] Saitama Med Sch, Dept Neuropsychiat, Saitama 3500495, Japan
[3] Rikkyo Univ, Dept Psychol, Tokyo 1718501, Japan
来源：
NEUROSCIENCE LETTERS | 2001年 / 315卷 / 03期
关键词：
medial prefrontal cortex; hippocampus; operant-type delayed alternation; temporal inactivation; working memory; perseveration;
D O I：
10.1016/S0304-3940(01)02366-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine the involvement of the medial prefrontal cortex (mPFC) in operant-type delayed alternation, microinjections of muscimol into the mPFC were used for temporal inactivation during behavioral tests in rats. The temporal mPFC inactivation showed effects related to both dorsal (decreased delay-dependent correct ratio, indicating working memory-related deficits) and ventral hippocampus inactivation (increased tendency to repeat errors) reported in our recent paper, without motor or sensory effects. These findings suggest that the mPFC integrates information from different hippocampal regions during a delayed alternation task. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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页码：129 / 132
页数：4
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