Systems Biology of Vaccination in the Elderly

被引:27
|
作者
Duraisingham, Sai S. [1 ]
Rouphael, Nadine [2 ]
Cavanagh, Mary M. [3 ]
Nakaya, Helder I. [1 ]
Goronzy, Jorg J. [3 ,4 ]
Pulendran, Bali [1 ]
机构
[1] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
[2] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30329 USA
[3] Stanford Univ, Dept Med, Stanford, CA 94305 USA
[4] Palo Alto Vet Adm Hlth Care Syst, Dept Med, Palo Alto, CA 94304 USA
来源
SYSTEMS BIOLOGY | 2013年 / 363卷
关键词
YELLOW-FEVER VACCINE; PNEUMOCOCCAL POLYSACCHARIDE VACCINE; TETANUS-ACELLULAR PERTUSSIS; HEPATITIS-A VACCINE; T-CELL RESPONSES; INFLUENZA VACCINE; ANTIBODY-RESPONSE; CONJUGATE VACCINE; IMMUNE-RESPONSES; DENDRITIC CELLS;
D O I
10.1007/82_2012_250
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Aging population demographics, combined with suboptimal vaccine responses in the elderly, make the improvement of vaccination strategies in the elderly a developing public health issue. The immune system changes with age, with innate and adaptive cell components becoming increasingly dysfunctional. As such, vaccine responses in the elderly are impaired in ways that differ depending on the type of vaccine (e. g., live attenuated, polysaccharide, conjugate, or subunit) and the mediators of protection (e. g., antibody and/or T cell). The rapidly progressing field of systems biology has been shown to be useful in predicting immunogenicity and offering insights into potential mechanisms of protection in young adults. Future application of systems biology to vaccination in the elderly may help to identify gene signatures that predict suboptimal responses and help to identify more accurate correlates of protection. Moreover, the identification of specific defects may be used to target novel vaccination strategies that improve efficacy in elderly populations.
引用
收藏
页码:117 / 142
页数:26
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