Architecture of the photosynthetic oxygen-evolving center

被引：2786

作者：

Ferreira, KN

Iverson, TM

Maghlaoui, K

Barber, J ^{[1
]}

Iwata, S

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

[2] ERATO, Japan Sci & Technol Corp, ATP Syst Project, Yokohama, Kanagawa 2260026, Japan

[3] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England

来源：

SCIENCE | 2004年 / 303卷 / 5665期

关键词：

D O I：

10.1126/science.1093087

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Photosynthesis uses light energy to drive the oxidation of water at an oxygen-evolving catalytic site within photosystem II ( PSII). We report the structure of PSII of the cyanobacterium Thermosynechococcus elongatus at 3.5 angstrom resolution. We have assigned most of the amino acid residues of this 650-kilodalton dimeric multisubunit complex and refined the structure to reveal its molecular architecture. Consequently, we are able to describe details of the binding sites for cofactors and propose a structure of the oxygen-evolving center (OEC). The data strongly suggest that the OEC contains a cubane-like Mn3CaO4 cluster linked to a fourth Mn by a mono-mu-oxo bridge. The details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed.

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收藏

页码：1831 / 1838

页数：8

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