E- and Z-Selective Transfer Semihydrogenation of Alkynes Catalyzed by Standard Ruthenium Olefin Metathesis Catalysts

被引：71
|
作者：
Kusy, Rafal [1 ]
Grela, Karol [1 ]
机构：
[1] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52,POB 58, PL-01224 Warsaw, Poland
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 23期
关键词：
STEREOSELECTIVE-SYNTHESIS; TRANSFER HYDROGENATION; TANDEM CATALYSIS; E-ALKENES; REDUCTION;
D O I：
10.1021/acs.orglett.6b03254
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Selective transfer semihydrogenation of alkynes to yield alkenes was achieved with commercial first and second generation Hoveyda-Grubbs catalysts and formic acid as a hydrogen donor. This catalytic system is distinguished by its selectivity and compatibility with many functional groups (halogens, cyano, nitro, sulfide, alkenes). The metathetic activity of the ruthenium catalysts may be utilized in tandem sequences of olefin metathesis plus alkyne reduction.
引用
收藏
页码：6196 / 6199
页数：4
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