Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity

被引：10
|
作者：
Gao, Fei [1 ]
Li, Ming [1 ]
Liu, Yinhui [1 ]
Gao, Chuanzhou [2 ]
Wen, Shu [1 ]
Tang, Li [1 ]
机构：
[1] Dalian Med Univ, Dept Microecol, Dalian 116044, Peoples R China
[2] Dalian Med Univ, Cent Lab, Dalian 116044, Peoples R China
来源：
GUT PATHOGENS | 2012年 / 4卷
关键词：
Intestinal dysbacteriosis; Peyer's patches; Immune response; T lymphocytes; Cytokines; INFLAMMATORY-BOWEL-DISEASE; DIVERSITY; FLORA; DYSFUNCTION; INDUCTION; CELLS; GALT;
D O I：
10.1186/1757-4749-4-19
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer's patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.
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