Mammographic density and breast cancer risk: current understanding and future prospects

被引:431
|
作者
Boyd, Norman F. [1 ,2 ]
Martin, Lisa J. [1 ,2 ]
Yaffe, Martin J. [3 ]
Minkin, Salomon [2 ]
机构
[1] Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2M9, Canada
[2] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[3] Imaging Res, Toronto, ON M4N 3M5, Canada
关键词
POSTMENOPAUSAL HORMONE-THERAPY; ESTROGEN-RECEPTOR STATUS; NESTED CASE-CONTROL; PARENCHYMAL PATTERNS; EXTRACELLULAR-MATRIX; TISSUE COMPOSITION; SUBSEQUENT RISK; TUMOR SIZE; ASSOCIATION; WOMEN;
D O I
10.1186/bcr2942
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is associated with a markedly increased risk of invasive breast cancer. The PMD phenotype is important in the context of breast cancer prevention because extensive PMD is common in the population, is strongly associated with risk of the disease, and, unlike most breast cancer risk factors, can be changed. Work now in progress makes it likely that measurement of PMD will be improved in the near future and that understanding of the genetics and biological basis of the association of PMD with breast cancer risk will also improve. Future prospects for the application of PMD include mammographic screening, risk prediction in individuals, breast cancer prevention research, and clinical decision making.
引用
收藏
页数:12
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