An orally active αV3 integrin antagonist inhibits the development of osteolytic lesions induced by breast cancer

被引:0
|
作者
Wesolowski, G. A.
Pickarski, M.
Neusch, G.
Sciola, D.
Adamson, G. E.
Sepp-Lorenzino, L.
Prueksaritanont, T.
Duong, L. T.
机构
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
96
引用
收藏
页码:S41 / S41
页数:1
相关论文
共 50 条
  • [1] An αvβ3 integrin antagonist (MK-0429) inhibits osteolytic lesions in breast cancer and melanoma lung metastases
    Pickarski, M.
    Wesolowski, G.
    Neusch, G.
    Prueksaritanont, T.
    Duong, L. T.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 : S187 - S187
  • [2] Prevention of breast cancer bone metastasis by an integrin αVβ3 antagonist
    Clezardin, P.
    Ctement-Lacroix, P.
    CANCER TREATMENT REVIEWS, 2006, 32 : S18 - S18
  • [3] A Monoclonal Antibody Against αVβ3 Integrin Inhibits Development of Atherosclerotic Lesions in Diabetic Pigs
    Maile, Laura A.
    Busby, Walker H.
    Nichols, Timothy C.
    Bellinger, Dwight A.
    Merricks, Elizabeth P.
    Rowland, Michael
    Veluvolu, Umadevi
    Clemmons, David R.
    SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (18) : 18ra11
  • [4] A peptidomimetic antagonist of the integrin αvβ3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy
    Carron, CP
    Meyer, DM
    Pegg, JA
    Engleman, VW
    Nickols, MA
    Settle, SL
    Westlin, WF
    Ruminski, PG
    Nickols, GA
    CANCER RESEARCH, 1998, 58 (09) : 1930 - 1935
  • [5] Potent, selective, and orally active antagonists of integrin αvβ3 as tumor angiogenesis inhibitors:: The discovery of the S 257-class of integrin antagonist.
    Rogers, TE
    Ruminski, PG
    Rico, JG
    Lu, HF
    Colson, PJ
    Awasthi, AK
    Nagarajan, SR
    Devadas, B
    Malecha, JW
    Chandrakumar, NS
    Nickols, GA
    Westlin, WF
    Meyer, DM
    Keene, JL
    Settle, SL
    Carron, CP
    Engleman, VW
    Freeman, SK
    Shannon, KE
    Knoerzer, DL
    Westlin, MM
    Nickols, MA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U40 - U40
  • [6] An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer
    Rausch, Matthew P.
    Hahn, Tobias
    Ramanathapuram, Lalitha
    Bradley-Dunlop, Deborah
    Mahadevan, Daruka
    Mercado-Pimentel, Melania E.
    Runyan, Raymond B.
    Besselsen, David G.
    Zhang, Xiamei
    Cheung, H. -Kam
    Lee, Wen-Cherng
    Ling, Leona E.
    Akporiaye, Emmanuel T.
    ANTICANCER RESEARCH, 2009, 29 (06) : 2099 - 2109
  • [7] An ανβ3 integrin antagonist MK-0429 inhibits breast cancer bone metastasis and melanoma lung metastasis
    Pickarski, M.
    Wesolowski, G. A.
    Neusch, G.
    Prueksaritanont, T.
    Duong, L. T.
    CLINICAL & EXPERIMENTAL METASTASIS, 2008, 25 : 62 - 62
  • [8] Conditional knockdown of integrin beta-3 reveals its involvement in osteolytic and soft tissue lesions of breast cancer skeletal metastasis
    Kovacheva, Marineta
    Zepp, Michael
    Berger, Stefan
    Berger, Martin R.
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021, 147 (02) : 361 - 371
  • [9] Conditional knockdown of integrin beta-3 reveals its involvement in osteolytic and soft tissue lesions of breast cancer skeletal metastasis
    Marineta Kovacheva
    Michael Zepp
    Stefan Berger
    Martin R. Berger
    Journal of Cancer Research and Clinical Oncology, 2021, 147 : 361 - 371
  • [10] Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis
    Pickarski, Maureen
    Gleason, Alexa
    Bednar, Bohumil
    Duong, Let.
    ONCOLOGY REPORTS, 2015, 33 (06) : 2737 - 2745